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The future of sustainable human health and agriculture rests on our ability to view microbial evolution as part of the solution rather than the problem. shoesmaker's heart Ankle Boots Female Lady shoes Comfortable Cashmere Leather Cloth Drilling Short Boots Ankle Boots Female Ladies shoes Shiny RhinestonesThe Koskella lab takes on this challenge by combining discovery-based science on plant microbiomes with hypothesis-driven experimentation. Our research examines host-microbe and microbe-microbe interactions by first identifying patterns in nature and then, in line with current theory where available,ESD shoes for Men - Slip Resistant Antistatic - StickyPRO ESD Safety shoesNine Seven Genuine Leather Women's Pointed Toe High Stiletto Heel Fashion Side Zip Handmade Concise Glossy Women Thigh Boots with Fastener Decors UNbox Men's Leather Flat Boots Tide Martin Pointed Chelsea BootsSJP by Sarah Jessica Parker Women's Meteor Sneakergenerating predictions to explicitly test in the laboratory using a combination of experimental evolution, microbial ecology approaches, Vionic Women's Fresh Joey Lace upand molecular biological techniques.
We focus primarily on how plant-microbiome, plant-pathogen, and bacteria-phage interactions occur, both as model systems for understanding fundamental principles and with the aim of leveraging these findings for design of novel disease management strategies. Adidas Mens F50 Adizero Fg Firm Ground Soccer CleatPIC PAY Benji - Women's Lace-Up Vintage Zipper Boot - Mid Height Wrapped Suede Leather Block Heel Ankle Bootie Black Suede 7.5MWe integrate ecological and evolutionary thinking with cutting-edge microbiological and molecular approaches to gain insight to microbiome establishment and function, within-microbiome interactions, and the role that microbiota and phages play in shaping disease. For more information on ongoing research projects, look here.
The Koskella lab at our end-of-semester lab lunch (May 2019)
A brief introduction to the lab and our recent research:
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I am an evolutionary ecologist interested in how species interactions influence genetic diversity within populations, diversity between populations, and species diversity at the community level. By combining evolutionary theory on coevolution, population dynamics, and infection genetics,Pelle Moda Women's Ivory bluesh Patent 7 M US MMarc by Marc Jacobs Women's Dot Fur Slide SandalWHL.LL High-Top Knee Roman Strappy Boots Back Zipper Heeled Sandals Fish Mouth Hollow shoes Open Toe Fine Heel shoes(Heel Height 11-13cm)GBX Men's Tate Ankle Bootie Black I directly test the underlying assumptions and predicted outcomes of host-pathogen and microbial interactions through the lens of human health and agricultural sustainability.
My previous work was primarily focused on host – parasite coevolution; first between a smut fungus and a plant (e.g. Kickers Mens Dark Grey Leather Kick Hi Boots), then a trematode and a snail (e.g. Anti Skid Rugs Silhouette of a Women shoes from Water color pinks 5'x6'), and most recently between bacteriophage viruses and the bacteria they infect, which are themselves parasites of plants (e.g. if phages are locally adapted to bacteria, T-JULY Women Black Velvet High Heel Thigh High Boots Ladies Faux Suede Round Toe Chunky Heel Over The Knee High Big Size Long Bootsand Women's Nike Alabama Crimson Tide Air Zoom Fitness CLG Week Zero College shoes - Size 7.5 US). The types of fundamental questions I’ve address are:
1) How do pathogens/parasites adapt to better infect their hosts? And at what scale / speed are they capable of adapting?
Meaden, S., & Koskella, B. (2017). Adaptation of the pathogen, Pseudomonas syringae, Tebapi Womens High-Heeled Pumps shoes Women shoes bluee Snake Printed Sexy Stilettos High Heels 12cm 10cm 8cm Pointed Toe Women PumpsTHERAFIT Women's Austin Denim pink clogs-and-mules 6.5 Mduring experimental evolution on a native vs. alternative host plant. Molecular ecology, 26(7), 1790-1801.
Koskella, B. (2014). Bacteria-phage interactions across time and space: merging local adaptation and time-shift experiments to understand phage evolution. The American Naturalist, 184(S1), S9-S21.
Koskella, B., Thompson, J. N., Preston, G. M., & Buckling, A. (2011). Nine West Women's Farfalla Leather Wedge SandalNike AIR Force 1 '07 LV8 3 'AIR Force 1 ' - AO2441-100Local biotic environment shapes the spatial scale of bacteriophage adaptation to bacteria. The American Naturalist, 177(4), 440-451.
Greischar, M. A., & Koskella, B. (2007). A synthesis of experimental work on parasite local adaptation. Ecology Letters, 10(5), 418-434.
2) How do hosts respond to this adaptation (i.e. coevolve) and become more resistant to their local pathogens/parasites? Sebago Women's Docksides Boat shoesZIBEN ZB174 - Boa Closure Lacing System Steel Composite Toe Safety Water Proof Construction Working Comfortable Lightweight Combat Work Boots shoes for Men & WomenAnd are they paying a significant cost for this evolved resistance?ZIBEN ZB174 - Boa Closure System Steel Composite Toe Safety Water Proof Construction Working Comfortable Lightweight Combat Work Boots shoes for Men & WomenAlegria Glee Women US 9 bluee Loafer.
Koskella, B., & Parr, N. (2015). The evolution of bacterial resistance against bacteriophages in the horse chestnut phyllosphere is general across both space and time. Phil. Trans. R. Soc. B, 370(1675), 20140297.
Meaden, S., Paszkiewicz, K., & Koskella, B. (2015). The cost of phage resistance in a plant pathogenic bacterium is context‐dependent. Evolution, 69(5), 1321-1328.
Koskella, B. (2013). Phage-mediated selection on microbiota of a long-lived host. Current Biology, 23(13), 1256-1260.
Koskella, B., Lin, D. M., Buckling, A., & Thompson, J. N. (2011).Josef Seibel - Sofia 21-71821873502Gabor Women's's Rollingsoft Low-Top Sneakers Kodiak CSA Work and Safety Boots BlackPatricia Nash Womens Roberta Leather Pointed Toe MulesThe costs of evolving resistance in heterogeneous parasite environments. Proceedings of the Royal Society of London B: Biological Sciences, rspb20112259.
3) Can antagonistic coevolution lead to increased diversity? For example, do pathogens/parasites preferentially target common hosts (i.e. the hosts that are the most fit) and therefore impose a rare-host advantage?
Morella, N. M., Gomez, A. L., Wang, G., Leung, M. S., & Koskella, B. (2018). The impact of bacteriophages on phyllosphere bacterial abundance and composition. Molecular ecology, 27(8), 2025-2038.
Koskella, B., & Lively, C. M. (2009). Evidence for negative frequency‐dependent selection during experimental coevolution of a freshwater snail and a sterilizing trematode. Evolution: International Journal of Organic Evolution, 63(9), 2213-2221.
and 4) Does this coevolution among hosts and parasites matter to human health, agriculture, and conservation? Can we use our understanding about when and how pathogens and commensals evolve to design better treatments and to predict and prevent the spread of diseases?
Koskella, B., & Taylor, T. B. (2018). Multifaceted impacts of bacteriophages in the plant microbiome. Annual review of phytopathology, 56, 361-380.
Lin, D., & Koskella, B. (2015). Friend and foe: Cole Haan Women's Anastasia City Sandal (65mm)Tahari Womens Ta-Bless Fashion Bootfactors influencing the movement of the bacterium Helicobacter pylori along the parasitism–mutualism continuum. Evolutionary applications, 8(1), 9-22.
Meaden, S., & Koskella, B. (2013). Exploring the risks of phage application in the environment. Frontiers in microbiology, 4, 358.
So far, the body of evidence produced by the scientific community over decades of work suggests that parasites can evolve rapidly and specifically to infect their hosts, but that this doesn’t always mean they get more harmful or even better at infecting.Fly London Womens Red Tily722fly Bridle SandalsWomens Open Toe Flatform Espadrilles Buckle Ankle Strap Sandals There is also clear evidence that hosts respond by evolving increased resistance, and that this often comes at a cost such as decreased growth or reproduction. This ongoing coevolution, in which neither parasite nor host is winning the battle has been called ‘Red Queen’ dynamics, based on the idea from “Alice Through the Looking Glass” that you have to run as fast as you can just to stay in the same placeHey Dude Men's RENOVAGREY Grey Fabric SneakersWomens Leather Hobo Bag Cross Body Shoulder Organiser Satchel Mila Black.Women's Open Toe Muller shoes High Heel Sandals Slippers Women's shoesDr. Brinkmann Damen-Pantolette blue (5) At last these ideas are beginning to be incorporated into the design and use of drug treatments (sometimes referred to as Darwinian Medicine) and used to build predictive models of disease spread in our increasingly-connected world. My work has taken advantage of a very powerful approach to address these questions by experimentally evolving hosts and parasites in the laboratory, Clarks Tri Form - 261324654 - color White - Size 7.5Bostonian Men's Pariden Wing Oxfordstherefore controlling for all the other “noise” out there in nature (Revere Genoa Women's Comfort shoes Removable Footbed Leather Slip-On).Ailj Snow Boots, Ladies Outdoor Leather Fluff One Booties Non-Slip Warm Boots Winter Cotton Boots UK 3.5-6.5 (Brown) (color Brown, Size 40 EU 7.5 US 6.5 UK 25cm JP)Ecco Trace LITE Outdoor Mid Hi Black However,CHAMARIPA Men's Height Increasing Light Weight Casual Sport Elevator shoes 2.76 TallerFiesso by Aurelio Garcia FI-7142 White Leather Silver Spikes Boot with Side Zipper I always try to go back to nature’s microcosm to find out whether what holds true in the lab can be used to explain what we see in the real world.Nine Seven Genuine Leather Women's Pointed Toe Stiletto Heel Classic Handmade Concise Business Thigh High Boots